THE EFFECTS OF EARLY CANNABIS USE AND THE RISK OF SCHIZOPHRENIA: A NARRATIVE REVIEW
Keywords:
Marijuana, Schizophrenia, Genetic predisposition to diseaseAbstract
Objective: This article seeks to synthesize the scientific productions on the association between the harmful use of cannabis during adolescence and the risk of schizophrenia. Methods: This is a narrative review by searching the Scielo, Pepsic, PNAS and Pubmed databases. Original, review and gray literature articles in English, Spanish and Portuguese were included in the study. The selection of articles, national and international official documents covered the period from 2012 to 2022, excluding articles that did not fit the theme. Results: The main evidences support a neurobiological correlation between the problematic use of marijuana and the development of schizophrenia in individuals with genetic predisposition, indicating that there is an influence of genetic and environmental factors, since the chronic use of marijuana can precipitate the emergence of Schizophrenia in genetically vulnerable individuals. Final considerations: Although the evidence does not consider a causal relationship between the chronic use of cannabis and the onset of schizophrenia, it is now known that cannabis is a risk factor in this process.
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